Wednesday, August 31, 2011

The Pop Culture Drug Blog (or the greatest chapter I will never get to use)


I discuss a lot how the mere concept of cognitive enhancement has obvious appeal among college students.  This makes prevention difficult when this concept is ubiquitous in the culture at large.  This dissertation aims to understand the broader conversations surrounding academically oriented drug use, including behaviors, beliefs, and the cultural influences that shape student beliefs.
            It deserves to be noted first that mental health, ADHD, prescription stimulants, marijuana ballot initiatives, FDA bans on Four Loko, and all of the other many drug-related issues mentioned throughout this dissertation are news.  Medical advancements are of public interest, and pharmacological advancements are covered in medical journals and academic peer-reviewed publications before subsequent controversies (e.g., overmedicalization in America, an ADHD crisis, too much legal pot, etc.) raise the level of the discourse to where it becomes cover fodder for mainstream magazines and lead material for broadcast news[1].
            In other words, cognitive enhancement is a known issue.  Joe got the idea to try Adderall after reading the article “Brain Gain” in The New Yorker (Talbot, 2009); Patrick from the pilot study cited the seminal editorial in Nature as his inspiration to seek nootropes (Greeley et al., 2008).  This proves that even responsibly written editorials or academic literature can inspire irresponsible—or at least illicit—drug use.  Our culture is replete with other cautionary and tempting stories about human enhancement in film, literature, and television that are both high- and lowbrow.
We’ll start with the highbrow.
            Aldous Huxley’s Brave New World is arguably the preeminent postmodern cautionary tale about the limits of human enhancement, but what’s most striking about the novel today is Huxley’s prescience, despite being first published in 1932, before genetics and Ritalin existed.  The fictional panacea drug “soma”[2] represented chemical escapism, but this was a cautionary tale.  Just as Huxley’s utopian society takes markedly dystopian trajectory, the rampant therapeutic use of soma is revealed to be more of a great chemical pacifier and stultifier of the human condition rather than an agent for its progress (Huxley, 2006)[3].  This is the opposite of what nootropics are designed to do.
            An earlier and perhaps more apt cautionary tale of human enhancement is Mary Shelly’s Frankenstein.  There could arguably be no more fitting enhancement allegory than a classic about creation, where a man (Dr. Frankenstein, of course) creates a superior being (Shelly, 2000).  Dr. Jekyll and Mr. Hyde also deals thematically with the consequences of a medically altered self (Stevenson, 1991).  Science fiction as a literary and film genre has produced countless works that incorporate similar themes, and there is no possible way for this discussion to meaningfully catalog them all.  The point is that human enhancement is not an uncommon plot premise.
Classic fictional takes on this enhancement narrative are usually not specific to illicit use of ADHD medications in educational settings.  Thus the participants in this study, or students in general, are not likely to get the specific idea to use Adderall non-medically through classic literature and films.  Contemporary popular culture however is different.  Here’s where it gets lowbrow.
Over the course of this approximately four-year research period, people have graciously reported all kinds of pop-cultural references to Ritalin, collegiate drug use, and other related topics, whenever they occur.  Though I cannot possibly comprehensively and exhaustively archive every “study drug” scene in television or film, or mention every episode of drug celebrity drug misbehavior occurring over nearly a half-decade, there are several worth noting.
When talking about prescription drug stigmas, participants often mentioned recently deceased celebrities.  Posthumous Oscar-winning actor Heath Ledger was the most commonly cited example during the pilot phase of research, but students interviewed months later for this dissertation brought up Michael Jackson more often[4].  In each of these cases, students discussed tragic celebrity overdoses to illustrate the realized harms of prescription drugs—but not specifically prescription stimulants.  In most cases, these deaths were caused by prescription opiates, sedatives, or combinations thereof, but not stimulants.  Frank, Kendall, and a few other participants felt that stimulants were less harmful and less negatively-stigmatized, but this study can’t conclude that all or most students will accurately discern the variable risks associated with different classes of prescription drugs.
            In terms of penetrating youth demographics, MTV has been a cultural presence since I was born.  The Emmy award-winning MTV series “True Life” has featured several mini-documentaries about alcohol, drug use, and college, including a 2003 episode “I’m on Adderall,” which chronicled the lives of three college students coping with varyingly severe non-medical prescription drug addictions (Sirulnick, 2003).  And after 25 seasons of fairly regular alcohol and drug consumption on MTV’s groundbreaking reality show “The Real World,” recent casts have included individuals with prescription drug problems[5].  Controversially, MTV adapted the BBC teenage drama “Skins,” in 2010, which featured liberal amounts of underage sex, lawlessness, and prescription drug abuse[6] (Elsley & Brittain, 2011).
            In the first season (2004) of the ABC network’s hit show “Desperate Housewives,” a key plot point featured one of its title housewives diverting Ritalin from her ADD-diagnosed children in order to clean the house, pick up her kids from soccer practice, and just to more expediently do general housewifery (Cherry, 2004).  The raunchy and seminal Comedy Central animated satire “South Park” also took aim at ADD and Ritalin in an episode from its fourth season (Parker & Stone, 2000).  As of this writing, the center of the popular culture universe seems to be orbiting around the speculation that actor Charlie Sheen might be on drugs.
In 2009 Middlebury College President Emeritus and Amethyst Initiative founder John McCardell appeared on the “Colbert Report” to discuss his campaign for higher education to reconsider the 21 year-old drinking age.  The host, comedian/political satirist Stephen Colbert quipped “this is one of the things I worry about: if we have freshman in college drinking, that alcohol will mess up the Ritalin and Adderall they’re taking to study for their finals. And the Provigil.” (Hoskinson & Colbert, 2009).
Stimulant medications and prescription drugs have made inroads within contemporary popular music as well.  The popular Grammy Award-winning Philadelphia-based jazz/hip-hop band “The Roots” seemed to make a daft commentary about the state of American education, juxtaposing the Columbine school shooting and overmedicalization in their 2006 song “False Media” where they sing: “America’s lost somewhere inside of Littleton / Eleven million children are on Ritalin.” (Trotter, 2006).  And Ryan, a participant, cited mainstream rap/hip-hop mogul Lil’ Wayne’s song “I Feel Like Dying” where the rapper discusses “jumping off a mountain into a sea of Codeine” and “[feeling like] a prisoner locked up behind Xanax bars” (Carter, 2004).
Mental health also seems to be prevalent in popular culture.  There are currently at least three reality shows about hoarding, a mental disorder listed in the DSM related to obsessive compulsive disorder.  There are reality series’ about drug interventions and celebrities undergoing drug rehabilitation.  Anecdotally, ADHD has become commonplace in our cultural lexicon; it is used often as an everyday adjective applicable to anybody rather than as a specified learning disorder affecting some, as in, “I’m totally ADHD right now.”
Then there are films.  Gabe credited “Charlie Bartlett” for giving him the idea to try study drugs, which is a 2007 rated-R comedy satire about an affluent high school student who feigned various psychological disorders in order to receive a litany of medications that he could in turn trade to peers in-need for money and popularity (Poll, 2007).  The film was a limited-release and not hugely successful commercially, but it was well received critically[7], and with regards to relevant issues surrounding doctor shopping and medication diversion, it is a great satire.
Charlie Bartlett” is a cutting and surprisingly accurate lampoon of our therapy and prescription-happy culture, but its scenes involving drug diversion was more of a vehicle for other character-based plot points.  Still, from the standpoint of somebody researching this exact topic, I could not have envisioned a more relevant or topical studio film.  Then “Limitless” came out.
Limitless” is an action-drama that was wide-released in early 2011[8], and it represents the ultimate manifestation of the modern “enhancement” dilemma (Burger, 2011).  Limitless” follows a struggling writer protagonist whose life changes completely when he discovers an experimental drug called “NZT.”  The movie is of course fiction, bordering on science fiction, but it touches upon many of the same psychological issues experienced by students in this dissertation research (mainly dependence, withdrawal, extreme swings in perceived self-efficacy, etc.).  Limitless” is such a fitting modern allegory for the “Frankensteinian” cautions or Faustian pacts of human enhancement because its feature substance, NZT, represents the ultimate nootrope.
In “Limitless” NZT is introduced as a prototype designer drug concocted through a vague confluence between the pharmaceutical industry and underground street chemists[9].  One dose lasts about a day, is worth $800, and it is awesome: on it, users can recall any information they’ve ever seen, instantly grasp complex concepts, harness complete creative control, and basically perform any mental function flawlessly and quickly.  (Side effects of NZT include: awesomeness, violence, balling out of control, occasional prostitute murder, severe psychological dependence, withdrawal, crash like symptoms, sickness, and death.  It may or may not also make you sort-of a ninja).
The relevant question asked in all of this is: are we the same people when we’re on drugs?  We tell troubled addicts that they are not the same when they’re on drugs.  This can be dear friends, family, or just people we know.  Alcohol and drugs are a problem for them.  And they know it’s a problem for them—neither they nor others want them to be on drugs because it’s a problem.
But therein lies the dilemma with enhancement.  Outwardly, nobody knows if there’s a drug “problem” because the problem manifests in success with work, school, or relationships.  Nobody cares if you’re the same person on drugs or not, because that person kicks ass.  Only you know—or wonder—if you’re the same person on drugs.  Maybe you even think you’re a better person on drugs[10].
            This is probably a greater occupational concern for students, soldiers, and athletes who occupationally confront these competitive and career-determining pressures to medicate (or in soldiers’ case, life-determining).
Professional athletics remains one of the more prominent concurrent examples of enhancement being played out in the court of public opinion, especially major league baseball.  As of this writing, Barry Bonds was charged with obstruction of justice in the federal case against his use of illegal performance enhancement drugs (undetectable steroids and HGH), and Roger Clemens has yet to resolve his considerable legal troubles against federal prosecutors[11].  These are arguably two of the greatest players—Bonds as a hitter; Clemens a pitcher—in baseball history, and the specter of their probable drug use looms as a testament to the reach of enhancement’s appeal[12].
Baseball, like cycling and other sports, also has a rich tradition of amphetamine use.  But with high profile steroid and HGH cases like Bonds and Clemens dominating the discourse, over a hundred professional baseball players quietly filed for “therapeutic exemption clauses” to the MLB’s less-heralded 2005 ban on amphetamines.  In the season prior to this ban there were only 35 exemptions, of which 28 were for ADHD medications (Blum, 2008).  In 2008, 103 of 111 exempt players were using ADHD medications.  This can’t be coincidental, and yet relative to steroids, nobody really cares.  Though different contexts, therapeutic exemption clauses and 504 plans undeniably present a similar type of opportunity for advantageous gamesmanship[13].
During a San Francisco Giants broadcast on August 13, 2010, a local network field reporter talked about Giants outfielder Andres Torres: “Andres Torres was a track star in Puerto Rico, and says it took him a while to develop as a hitter, but there's another reason why he got it going late: he was diagnosed with ADD in 2002, but didn't start taking medication until 2007 during his second stint with the Tigers organization,” (CSN, 2010).  Looking at Torres’ career stats, his highest batting average prior to 2007 was .220 (168 at-bats in 59 games in 2003, which is not a lot), he then struggled in 2004, was subsequently demoted to play in the minor leagues for a couple years before returning to the major league (Detroit Tigers) in 2007, and then the Giants in 2009 where he batted .270.  Last season he batted .284[14].  Thus for guys like Torres, it’s possible Ritalin can make or save your career[15] (Torres’ 2010 salary was $428,000; in 2011 it is $2.2 million; ESPN, 2011).
College students clearly feel similar competitive pressures to medicate, with many reporting successful outcomes.  This begs the question of what exactly is “responsible” use when it comes to enhancement drugs?


[1] I’ve used several Time and Newsweek magazine covers featuring Ritalin, ADHD, and prescription drugs, and several TV news magazines have covered the issue as well, most recently 60 Minutes, with Katie Couric interviewing Alan DeSantis and several other researchers cited in this dissertation (Fager, 2010).
[2] Not to be confused with the opiate medication soma that is currently available on the market, though I suspect its etymology may come from Brave New World.
[3] Ironically, Huxley in real life became quite an advocate for the therapeutic and spiritual use of mescaline, chronicling his experiences with the drug in 1954’s The Doors of Perception (Elliott, 2003).
[4] Actress Brittany Murphy, musician “DJ AM”, and Comedian Greg Giraldo were also mentioned.
[5] Mainly presciption opiates, but alcohol and other illegal drugs are pretty constant.  Please don’t ask me how I know this.
[6] The ensuing controversy had many advertisers abandoning MTV and the show.
[7] It received a 56% positive rating on Rotten Tomatoes as of April 27, 2011 (rottentomatoes.com, 2011).
[8] Serendipitously, I first caught wind of this development about a year ago, when my roommates got teamed up with Andrew Howard for 9 holes of golf at Griffith Park. (Howard played an Eastern European goon, arguably the movie's main bad guy).  He told them about his current project at the time—a movie about a miracle brain drug that grants super cognitive powers and turns lives around. They came home and said “Dude, I think they’re making a movie about your dissertation …”
[9] The small pills are about the size of a 20mg tablet of methylphenidate, only translucent, resembling those clear plastic rubber tabs that you stick on the inside of IKEA desk drawers to keep them from slamming.
[10] This is the central thesis in Carl Elliott’s “Better Than Well,” cited in the Literature Review and throughout this dissertation (Elliott, 2003).
[11] But it’s not looking good for “The Rocket.”
[12] On April 8, 2011, Tampa Bay Rays outfielder Manny Ramirez announced his sudden retirement from baseball after his third positive test for banned substances. Ramirez was issued a 50-game suspension after his second positive test as a member of the Dodgers in 2009-10, and rather than receive the 100-game suspension for the failed third test, he retired.  Sports critics widely speculated that Ramirez—widely regarded as one of the greatest right-handed hitters ever—has no chance to be voted into baseball’s Hall of Fame despite career statistics that would otherwise merit near-automatic induction (Stark, Rojas, & Padilla, 2011).
[13] Maybe not quite though.  If the medical exemption clause was truly like 504-plans, then Andres Torres, Texas Rangers All-Star Ian Kinsler, and the over 100 other exempt players would be given four and a half strikes instead of three.
[14] Which is relatively good, or at least vastly improved from his early career numbers.  Batting averages represent percentages of at-bats that are hits, thus a .284 means that Torres safely reached base 28.4 percent of his at-bats.  Batting around or above .300 is statistically considered very good, potentially all-star worthy.
[15] And all you have to do is tell a doctor you can’t concentrate?  Who wouldn't do that?  (Footnote-footnote: I first wrote this piece of discussion as a blog entry in August focusing on Torres and Kinsler; serendipitously, both teams later reached the 2010 World Series, which the Giants won).

Friday, August 12, 2011

Drug blog back from break!

I think I've started the past few entries by apologizing for being such an irregular blogger ... that streak ends here!  Dissertating is not easy, but it is (almost) over.  Here's the deal: it's been an intense past few month stretch, I defended (!), graduated (!!), but have yet to formally file.  For those as unfamiliar with the idiosyncrasies of academia as I apparently was, in order to officially get my degree (as in the actual, physical piece of parchment), a finished dissertation has to be officially "filed" where it is meticulously checked page by page with a microscope by a librarian.  This process, according to a friend and recent graduate is "a total pain in the ass."

So I'm looking forward to that soon.  I have a bunch of blogs saved up on my hard drive (cloud? Never!) and many of them are about sensitive academic politics.  For my friends and most nerds, such juicy gossip and commiseration would likely be welcome.  But I'd like to wait until I actually get my degree before griping on a public blog about university policies and people who still hold my future in their hands.  Plus, c'mon, as much as I attempt to anonymize myself and human subjects, I'm barely anonymous.  In fact, I think my Android phone may have automatically outed me via Google+.

So drug blog posts ripping on the dissertation process will have to wait until later.  And though the dissie is almost done, this blog is not.  I had 645 pages of pharmacological poetry that I whittled down to 250, that extra type will end up here for sure.  A look at entries/deleted chapters to come:

- Conference feedback: "I can't believe he didn't know about bath salts!"
- What we can all learn from 4 1/2 episodes of "Intervention"
- Weed law changes: watch out, Chico!
- I got a new job! (hopeful entry)

Monday, June 20, 2011

"Can I have my drugs now?"

After so many years of writing for the Daily Bruin, I wrote my final column a few weeks ago about the culmination of my research to date.  Below is my version, which I think the editors tweaked a little (and made up their own (inferior) headline) for the version found online here:

http://www.dailybruin.com/index.php/article/2011/05/student_use_of_stimulant_drugs_unavoidable

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Four years ago I started researching students who used drugs like Adderall and Ritalin for academic purposes.  Maybe you’ve seen my flyers around campus or have a friend who was actually brave enough to sit down with me and let me interview them.
This project became my dissertation, which is almost finished, as is my time at UCLA.  But if I could summarize the culmination of my graduate education into a single bold statement/prediction, it would be that college students really like their drugs, and see no compelling reason to stop doing anything that they see as potentially enabling their success.
Before I go any further, I want to apologize in advance to anybody who reads this and was previously unaware of the dilemma of cognitive enhancement.  It’s the kind of topic that makes any prevention-oriented research self-defeating, since the idea alone of a drug with academic utility is bound to be virally appealing in fiercely competitive climates like UCLA.
In other words, how can I, or any researcher, talk truthfully about cognitive enhancement in the name of prevention or “responsibility” without making it sound appealing to anybody?
It’s not for everybody.  Stimulant medications are controlled substances with physiological, psychological, and legal risks.  But the truth is that many college students feel that the associated risks are far outweighed by the academic benefits of use.  What’s even more problematic is that research doesn’t completely disagree.
Concern over collegiate “cognitive enhancement” is nothing new, but higher education has done little since ADHD-diagnosed students first began bringing their renewable Ritalin prescriptions to college in the mid 1990s.  Word quickly got out that there was something “better” than coffee.
National databases on collegiate substance abuse put non-medical use of stimulant medications at around 8%, which doesn’t include the approximately 7.5% of American students diagnosed with ADHD.  Independent studies conducted on college campuses report illicit use prevalence at 25% and as high as 34%, with over half of upperclassmen and students in Greek life having used prescription stimulants.
From The Beatles and Elvis to JFK and Hitler, speed scares are not without historical precedent.  Desoxyn and Pervitin were used heavily by both allied and axis military soldiers in World War II, (Provigil and Adderall are still used today by British forces and Air Force pilots).  The then over-the-counter stimulant Benzedrine allowed Jack Kerouac to pen “On the Road” in 20 days, while domestic use of amphetamine pills were immortalized in the Rolling Stones’ song “Mother’s Little Helper."
Two things separate this generation of stimulant use from the past: medical sophistication and the advent of ADHD.  Today’s drugs are better, and we’re vastly more knowledgeable about what they do.  Leading clinical researchers and bioethicists have recently started conceding that these drugs may actually work, leading to real gains in concentration, memory, and sustained cognitive performance.
ADHD is a different kind of game changer in that it medically legitimizes the everyday use of amphetamines for a relatively broad swath of the population.  This separates our current dilemma with prescription amphetamines over controversies in past decades.
Despite skepticism from conservative pundits, the Church of Scientology, and my dad, ADHD is a real condition with real genetic determinants.  It is about 70% heritable, which is as much as height, or blood pressure.  But this doesn’t mean that our diagnostic system isn’t flawed.  Many savvy, opportunistic students and parents have been known to feign ADHD symptoms just to seek medications.  This is called “doctor shopping.”
I certainly saw some of this in my own research, but it was surprising to see how the situation with unstoppable drug-seeking behavior mirrored the burgeoning medical cannabis scene that erupted throughout Los Angeles over the past several years.
I recruited students who used “any drug” for academic purposes, and to my surprise, many inquired about using marijuana and salvia (which is currently legal) for creative purposes.
Whether you find the premise of creativity-enhancing drug use plausible or not, there is an historical precedent for that too.  Literary greats generally preferred booze, but prolific drug using artists and intellectuals included the beat poets and bebop jazz generation, Francis Crick, Aldous Huxley, and again, The Beatles.
As seen with medical cannabis, some drug policies seem to be in flux, or at least newly reopen to public debate.  Distinguishing what’s legal or illegal, however, isn’t as important as what’s “responsible” or “moderate,” and it may be moot if anybody can get what they want, whenever they want.  We may be there already.

Wednesday, April 20, 2011

4-20 Special: Why ADHD meds are better than weed ... to deal

The following is an excerpt from my "Discussion/Conclusion" chapter.  It being April 20th today, a doobieous day for so many college students, I thought it appropriate to post some of my findings related to cannabis use.  This piece discusses the financial incentives for a prospective dealer of ADHD medications (controversial!), and concludes that if you're a weed dealer on a college campus, you're in the wrong game (even more controversial!).  Enjoy.

There are several advantages to quasi-licit use achieved through doctor shopping. First of all, it’s legal. Second, it’s safe; you know what you’re getting. The “safety” of dealing stimulant medications is not a concern to begin with, but several illicit users had concerns about what they were taking. This is not to say that illicit drug diversion can’t be dangerous or “sketchy.” As seen with “operation sudden dawn” and “operation Ivy league” with the experiences of several participants, dealers of illicit medications may be the same dealers who peddle more dangerous street drugs. Sometimes interactions can be unsafe, or the products can be of questionable. Getting it from a doctor is cheaper, more convenient, and certainly safer.

Another advantage is simply having a consistent, reliable, and price-controlled source. Especially with health insurance, nootropic medications obtained directly through pharmacies are much cheaper than typical WCU illicit market prices. Looking closely at the specific price differences, it’s easy to see why savvy or entrepreneurial students would consider feigning ADHD symptoms for profit, rather than (or in addition to) primarily for their own personal use.

For example, student patients with the WCU student health insurance plan can fill a prescription for 30 20mg pills of generic methylphenidate or dextroamphetamine for $15; $30 if they choose the drugs by their respective name brands, Ritalin and Adderall (citation omitted). Considering that illicit users seldom discern what they take, let’s assume that the profit-motivated hypothetical dealer opts for generics: $15 for 30 pills. Students quoted many prices for a single Adderall or Ritalin pill, depending in part on potency (mg) and release formulation. Just to control for this hypothetical example though, an oft-quoted average price was $5 (even though Mike reported selling Adderall at peak times for as much as $30 for a single pill). A student could therefore resell his/her $15 prescription for $150—a ten-fold markup. A patient could refill this prescription monthly, bi-weekly, or even more frequently, depending on the patient and prescribing physician. If you factor in higher prices for higher dosages or extended-release formulations, or varying market dynamics (read: finals), diverting ADHD medications in college can be extremely lucrative.

This study echoes earlier research callings to urge student health centers to exercise extreme caution, both when diagnosing ADHD, and when prescribing treatment medications (Harrison & Rosenblum, 2010). With on-campus pharmacies at many large universities offering even better price discounts, dealing could hardly be more convenient or profitable.

Being college students, cost is a huge barrier for many. A lot of participants found the prices of Adderall prohibitive; for many it was the same with weed. Unlike stimulant medications however, most insurers do not cover medical cannabis, and the illicit market value of marijuana is nearly identical to its store price (at least it’s nothing close to the approximately 1000% markup hypothetically outlined). This offers relatively little financial incentive for prospective dealers to consider diverting medical marijuana over ADHD medications, and considering that medications are small, concealable, logistically easier to divert, with very little perceived concern among dealers getting caught. All of this amounts to arguable advantage for licit users, who include doctor-shoppers-turned-dealers of ADHD medications.

Friday, March 25, 2011

“Limitless” ... the movie review this blog has been waiting for.


So apparently there’s a full length motion picture about my research.  It’s called “Limitless” and it stars Bradley Cooper and Robert DeNiro.  It hit theatres last week to consistently lukewarm acclaim (currently 66% on Rotten Tomatoes).
I first caught wind of this development about a year ago, when my roommates Erik and Conrad got teamed up with Andrew Howard for 9 holes of golf at Griffith Park.  (Howard played an Eastern European goon, arguably the movie's main bad guy).  He told them about his current project at the timve—a movie about a miracle brain drug that grants super cognitive powers and turns lives around.
They came home and said “Dude, I think they’re making a movie about your dissertation …”
And sure enough, the film is pretty much right on target.  Let’s get something straight: it is fiction—almost science fiction.  But it’s set in the current day, and any scientific leaps are well disguised so that credibility isn’t an issue where it affects the enjoyment of the movie … (except for perhaps a couple places that I will NOT mention, but I research phenomena specifically related to neurocognitive enhancement, so I might be a tough critic when it comes to the science behind some of the fiction).
A week ago at the NASPA conference in Philadelphia, I played the trailer for “Limitless” off YouTube as people were sifting into my session.  I’ve never seen a presentation NASPA or any other conference with movie trailers, but it seemed to go over well.  I couldn’t claim that the movie was any good or not, just that—based on the trailer—there seemed to be a 99% chance that it related to the ensuing presentation and discussion.  And indeed, it did.
After seeing the movie this morning, I give “Limitless” a solid 6/10 just as a movie experience to a lay audience.  Not groundbreaking entertainment, but enjoyable.  If you are not a 30-something social science researcher and drug behavioralist, that’s about what you will think of this movie.  I wish I could give it more because I want everybody I know to see it.
Because for me personally, I absolutely loved “Limitless” and give it a 10/10.  I tend to strongly root for any media product that pushes my topic more toward the mainstream, and “Limitless” is the ultimate manifestation of the modern “enhancement” dilemma.
Not just is it totally about my research, but there were serious moments where I thought that this movie might be about me, specifically.  It’s set in New York, where I was recently and have an affinity for.  Bradley Cooper’s character Eddie Mora is a stressed out writer with medium-length hair, stubble, and insecurities about his career and relationship prospects. [1.]
Then he gets the drug.
The drug in “Limitless” is something called MDT, a brand-new prototype designer drug originating from a foggy confluence of the pharmaceutical industry and street chemists.  Whatever the source, the small pills are translucent and look like the tiny, rubber tabs that you stick on the insides of IKEA desk drawers to keep them from slamming.
The effects of MDT—which I would swear was NCT or NZT when the actors talked about it, yet according to IMDB, it’s MDT—last about a day per pill, and it is awesome.
Theoretically, MDT represents the ultimate nootrope.  On it, users can recall any information they’ve ever seen, instantly grasp concepts, harness complete creative control—basically perform any mental function perfectly and quickly.
The pusher in the movie claims that the human brain normally operates at only 20% capacity (I’d like to see a footnote on that …), and that MDT allows the brain to access the optimal 100%.  In high school I took Ritalin and felt a little bit more alert and confident studying for AP Bio, but nothing like a five-fold increase with photographic retention and recall.
A single dosage of MDT is worth $800.  Adderall usually goes for around $5 on most college campuses.
Side effects of MDT include: awesomeness, violence, balling out of control, occasional prostitute murder, severe psychological dependence, severe withdrawal and crash, sickness, and death.  It may or may not also make you sort-of a ninja.
I really can’t say anything more without spoiling the plot, but since I haven’t really talked about the plot at all, I think we’re safe.
From a psychological research perspective, I love this movie because it does a great job of laying out all of the key devices in a way that effectively comes to represent the ultimate existential crisis we face neurochemical enhancement technologies.
In other words, there are real psychological constructs at play in this movie, particularly psychological dependence/reliance.  Are we the same people when we’re on drugs?
We tell troubled addicts that they are not the same when they’re on drugs.  This can be dear friends, family, or just people we know.  Alcohol and drugs are a problem for them.  And they know it’s a problem for them—neither they nor others want them to be on drugs because it’s a problem.
But therein lies the dilemma with enhancement.  Outwardly, nobody knows if there’s a drug “problem” because the problem manifests in success with work, school, or relationships.  Nobody cares if you’re the same person on drugs or not, because that person kicks ass.
Only you know—or wonder—if you’re the same person on drugs.  Maybe you even think you’re a better person on drugs.
Most of the drugs I study (mostly stimulant meds like Ritalin and Adderall) are strong enough that they create this dilemma among users.  And most college students who participated in my study are young, still developing their identities, and sometimes don’t know where to attribute their academic successes: to the self, or medicated-self?
“Limitless” represents the ultimate existential dilemma of enhancement in society, partly because MDT represents the ultimate drug.  The life of Eddie Mora is the perfect stage for these drug-related tradeoffs to play out.
SPOILER ALERT:  My only problem with the movie is that the answer to every crisis or every plot pickle is … more drugs!  Need to finish that novel quickly?  Better take drugs.  Thugs chasing you through Central Park?  Drugs!  Goons crashing your apartment to murder you?  More drugs!
[End spoiler alert ... probably].
However, as a society, our increasing pharmacological reliance is also problematic—we have better drugs to help us from worse drugs, and more drugs to alleviate more problems.
So as a movie, I wish that MDT wasn’t the solution to everything.  It’s too much like the invincibility star in Mario Bros. or like spinach to Popeye—once it’s on, it’s on—goombas and Bluto stand no chance.  No surprises, ever.
The only suspense seems to come when the panacea is no longer available.  Then what?
That was probably the most difficult question I asked stimulant-using college students: “when do you plan to stop taking Concerta?  What would happen if you suddenly no longer had access to Focalin?”  There are drawbacks to feeling limitless.  And as a movie making a statement about the limits of enhancement, I really enjoyed “Limitless.”
10/10 for me personally ... 6/10 for everybody else.

Correction (3.28.11) : I had previously, erroneously, reported that Erik and Conrad's fateful golf pairing was with two production assistants on "Limitless" ... I received very prompt clarification from both of them, that it was instead key actor Andrew Howard, who turned in a fine performance as—essentially—Niko Bellic from Grand Theft Auto IV.  Still waiting for the correction from Mr. Howard that they swing a golf club like Charles Barkley.

1. Nobody else?  Just me?  Is somebody in Hollywood reading my dream journal?  At the early-bird matinee of the Century Redwood City 20 this morning, I even had the coffee pangs, stubble, and corduroy jacket of a pre-superdrug Eddie Mora.  The similarities were comical.  I laughed many times out loud at inappropriate moments, much to the bewilderment of the dozen or so other thrifty moviegoers in the audience with me.

Tuesday, January 25, 2011

My results chapter is bigger than Jupiter

... but you know what they say about a guy with a big results chapter?  ... Probably that he'll never graduate, seriously, I don't know.  What do they say?  Well, mine is clocking in at around 100 pages so far (single spaced), and according to my outilne, I'm like half done with it.  A lot of that is thanks to the participant briefs that I've been posting on this blog (41 of them!).

But I haven't posted any actual results snippets, or my own analyses ... until now.  Out of the 102 pages to-date, these are probably the 3 best.  Enjoy:


Access to nootropics as an issue of social equality and fairness

Several participants felt that prescription stimulant use was more frequent among certain ethnic student groups on campus.  Many even had theories on why that was the case, speculating that socioeconomic class standing also had something to do with observed prevalence disparities, which included both illicit and licit use.

Kyleen felt that her parents were out of the ADHD-loop because they held a different cultural regard for psychology and pharmacotherapy (she identified as Vietnamese): “I don’t think Asian people really accept that [ADHD] is a disease sometimes, because they’re not really aware of the more social diseases, I guessI think it’s just coming from a country that’s less developed.

Alexis, a student of Middle-Eastern descent who was diagnosed with ADHD, thought that both licit and illicit ADHD medication use was less common among her Asian peers (she was in engineering, which, as she said, is largely Asian), and more common among white students:

Alexis:             I would say more white kids are doing drugs than the Asian kids.  There’s a lot of Asian kids in my department.  It’s a little different.

Interviewer:            Why do you think white kids, is that just an observation?  Or are there reasons that you think that might be the case?

Alexis:            Yes, for economic reasons.  We can afford it.  We’re kind of bored.  It’s a little cultural.  You’re not going to see many drugs in the Asian cultures.  You’re just not going to see it.  They don’t really use it.  They don’t go crazy.  I don’t even see them drink that much coffee because they have that discipline.  My family really frowns on medication.  Well, not medication but drinking and stuff like that.  So that’s why I am the way I am.  But some of the families that I have seen that have taken medication for ADHD haven’t sought any alternative.  The ones that I’ve seen have all been white.

            So in addition to ethnic and cultural factors, Alexis saw a correlation between economics and ADHD-medication prevalence.  But—not to be overlooked—it’s also boredom.  It may seem like a trivial, or perhaps-cynical thing to say, but boredom actually was a recurrent data theme in terms of why participants felt that certain types of students are more likely to use prescription drugs[1].  Said Alexis:

I particularly avoided going to a white school really, for high school.  Just because the amount of drugs was way higher for some reason.  I didn’t understand why, maybe it was money, or cause they were bored, that’s what it seemed like most of the time.  And then I went to an intellectual high school and they were doing drugs for more creative purposes.

It is interesting to note for later discussion that Alexis felt that the “intellectual” atmosphere in her high school was more prone to creativity-oriented drug use, but for the sake of explaining the convergence of with class, boredom, and drugs[2], Kelly agrees:

I grew up in a town where everyone’s rich and all the kids don’t have anything to do.  All their families are rich so they don’t have any motivation to do anything special with themselves.  I didn’t like my town, so I had motivation to get out and do something for myself, but there were those few times …  That’s basically where all my drug experimentation comes from, it’s like, “Well, I’m bored.  Let’s fuck around.”  So we had just gotten piercings, and my friend was like, “I have some Adderall and I’m kinda tired; do you want to try it?”  And I’m like, “Okay.”  So we really just tried it for fun the first time, just to see what it was like, and it was just a little perk.[3]

Ryan, who identified as mixed Latino and Irish descent, had a long, rich dialogue with the researcher about the socoeconomic parameters that he felt influenced this specific type of academically-oriented prescription stimulant-seeking behavior in college.  It is a long excerpt, and Ryan speaks with an urban inflection—both the length and vernacular were minimally edited in order to contextualize the authenticity of the subject.  Here Ryan starts by describing how the “urban community” regards ADHD symptomology:

Interviewee:            Basically how I like to put it, in society it's like, in the urban community, when you had energy and you think a lot and all this process, your parents say to go outside and play, go kick rocks, go play with your friends, whatever's clever for the parent to utilize that … because there's not really any money for funds for healthcare for anything like that—for Adderall—for a doctor to diagnose you and take care of that. 

Interviewer:            Is it about the money?  Or is it about kind of like the knowledge to get that going?
 
Interviewee:            It's both.  It's both, because the parent also doesn't understand 'cause she never grew up.  Nine times out of ten, the parent that grows up in the community stays in the community, because she has that "the world is flat" type of idea.  And so the only way they know how to survive is to follow the parents' tracks.  And it's sad, but that's the reality.  Now if they grew up never knowing, and when they were all hyper and everything, they're going to do the same thing to their children.  The apple doesn't fall far from the tree, exactly.  So when it comes down to it, it's the parent that doesn’t' know.  Then when they [the kids] get to college, or for whatever reason, they get somewhere to a different area, you learn just like I learned, this is like cheating.  You take Adderall – you take this medication for all my thoughts, and you control it, and you have this outburst come out, and I'm like constantly just thinking about it.  I'm like, this is great.  It's unheard of.  And then when you come up to the, I want to say, suburbs, or well-off people—as we say in [my neighborhood], "the people on the hill"—basically they have the knowledge.  Their parents are educated.  They know what it takes 'cause they've already been through the whole history – through the cycle to know what their child needs to continue to grow and learn.  So I tell people, this whole Adderall thing is the white version of cheating.  You want to get good grades, you want to do everything – you want to know why you has a 4.3 GPA, or whatever, and he does all of that?  There's a reason.

Interviewer:            So you think these things are a real advantage?

Interviewee:            Yes. 

Interviewer:            And you think that urban families are sort of missing out? 

Interviewee:            Yeah.  It's like, you know, they say George Bush took a few days to get to New Orleans after the hurricane [Katrina] … if they find out about it, okay, we'll meet their needs, but until then, they're still dumped on and they do not know it. 

Interviewer:            Interesting.  And this is based on your experiences throughout like, lower school?  High school?  When did you start to notice or become aware of this?  I mean, was this after you found out about Adderall yourself?

Interviewee:            Well, I've been through foster homes as a child.  I've been through juvenile hall.  I've been through different associations with family members, and growing up in different communities all throughout California.  So it's like I've been in all these different settings and I've seen these different kids and how they react, and then when I get to college, I get put into this rich environment of Santa Barbara, and it's like the drug alcohol-friendly area.  And then my mind is just –

Interviewer:            You mean Isla Vista? 

Interviewee:            Oh, yeah, Isla Vista, and – yes.  I spent many, many days in Isla Vista.  [Laughter].

Interviewer:            Okay. 

Interviewee:            Yeah, being drunk as hell.  But, yeah, and they introduced me to Adderall, and the next thing I know I'm writing a ten-page paper, and never knew I could write ten pages.  … I call that the white version of cheating.  That's like, quote-unquote. 

Interviewer:            But that's interesting.  Then why do you think it's cheating – specifically?  Or the white version of cheating? 

Interviewee:            'Cause like – well, I've definitely grown up in many urban societies, like poverty-stricken to the fullest extent, and there's definitely no people of my skin color in that area.  And my skin color is light and it's like, okay.  And then I go into Santa Barbara where it's 65 percent white, and then it trickles down.  It's like 2.8 percent black people, and 3 percent Asian, and like 10 percent Mexicans.  It's pretty crazy.

Interviewer:            Sure, sure.

Interviewee:            So basically I go there and I learn about the drug.  And off the top I learned it from a couple people who I – really, I never grew up with too many white friends, and then I go to Santa Barbara and I have all these white friends.  It's pretty amazing.  Like, I didn't know you guys act like this.

Interviewer:            Right, right.

Interviewee:            And I learned the drug, and it's was like, okay, that's the white version of cheating. 

Interviewer:            Do you think that it’s cheating if they have attention deficit disorder?

Interviewee:            It's cheating 'cause they got the help – well, no, I can't call it – that's something I definitely cannot do.  I can't get mad at the next person for what they had the benefits of.  Like, that's envious, and I'm definitely not envious of what's been.

Interviewer:            And these are, again, the students who have been diagnosed with something – 
 
Interviewee:            Yeah, right.

Interviewer:              and they're given it for that?

Interviewee:            Yeah, I definitely don't think that – like I don't envy 'em at all. 

Interviewer:            Okay, even though these are the kids who are also selling it to you and other people?

Interviewee:            Yeah, I mean, if you find $100 on the ground, it's up to you if you're going to share it with the next person, or you're just going to spend it all on yourself. 



[1] Availability is also an obvious precondition.
[2] Pop-cultural footnote: it seems like the teenage drama “Skins” is built entirely around the formula that boredom + youth = drug use (especially prescription drug use).  This show became popular in America and Britain as a BBC series.  The jury is still out on the even-more-recent American adaptation produced by MTV, but my current high school students say the Brits did it better (like so many other shows).
[3] Subjectively, Kelly’s anecdote completely sounds like an episode of “Skins

Sunday, January 2, 2011

Smokin' on mistletoe: the holiday post

Were Santa and his reindeer just a drug-addled hallucination?  Conventional wisdom holds that the red and white Santa Claus as we predominantly know him was a Coca-Cola concoction from Madison Avenue, but a recent NPR report seems to think: maybe shrooms had something to do with it.

Keep in mind that Harvard has a famous history with formalized, ostensibly empirical shrooms research.  Remember the Harvard Psilocybin and Harvard Psychedelic Research Projects (both under the guise of Timothy Leary)?  It looks like fair Harvard has kept with this tradition, especially for the holidays:

http://www.npr.org/2010/12/24/132260025/did-shrooms-send-santa-and-his-reindeer-flying